Stoichiometric inhibition of mammalian dihydrofolate reductase by the gamma-glutamyl metabolite of methotrexiate, 4-amino-4-deoxy-N-10-methylpteroylglutamyl-gamma-glutamate.

Subjects

Subjects :

Animals
Cell Division drug effects
Cells, Cultured
Chromatography, Gel
Dose-Response Relationship, Drug
Glutamates
Leukemia L1210 enzymology
Methotrexate pharmacology
Mice
Structure-Activity Relationship
Folic Acid Antagonists
Methotrexate analogs & derivatives

Details

Language :

English

ISSN :

0006-291X

Volume :

63

Issue :

3

Database :

MEDLINE

Journal :

Biochemical and biophysical research communications

Publication Type :

Academic Journal

Accession number :

1131258

Full Text :

https://doi.org/10.1016/s0006-291x(75)80439-6