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The antioxidant enzyme quinone reductase is up-regulated in vivo following cerebral ischemia.
- Source :
-
Neuroreport [Neuroreport] 2001 Apr 17; Vol. 12 (5), pp. 1045-8. - Publication Year :
- 2001
-
Abstract
- An astrocyte antioxidant enzyme, quinone reductase (QR), was studied in vivo to assess whether its activity was up-regulated following cerebral ischemia. Rats were given a unilateral focal cerebral infarct and regions of interest within the ischemic penumbra compared to the non-ischemic side for QR activity. At 7 days post-ischemia, QR activity was significantly up-regulated within cells of astrocyte morphology in the cortex (p = 0.007) and subcortical (p = 0.005) areas adjacent to the infarct. This enzyme activity peaked at 7 days but was still significantly up-regulated at 14 days. Up-regulation of QR activity occurs within the ischemic penumbra of a stroke in this animal model and may contribute to factors that limit ischemic damage to neurons in this area.
Details
- Language :
- English
- ISSN :
- 0959-4965
- Volume :
- 12
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Neuroreport
- Publication Type :
- Academic Journal
- Accession number :
- 11303743
- Full Text :
- https://doi.org/10.1097/00001756-200104170-00036