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Complement association with neurons and beta-amyloid deposition in the brains of aged individuals with Down Syndrome.
- Source :
-
Neurobiology of disease [Neurobiol Dis] 2001 Apr; Vol. 8 (2), pp. 252-65. - Publication Year :
- 2001
-
Abstract
- To study the link between beta-amyloid (Abeta) and neuroinflammation, we examined the levels of complement as a function of age and extent of Abeta deposition in Down Syndrome (DS) brain. C1q, the first component of the complement cascade, was visualized using immunohistochemistry in the frontal, entorhinal cortex, and hippocampus of 12 DS ranging from 31 to 69 years of age. C1q was consistently associated with thioflavine-S positive Abeta plaques in DS brain and increased with more extensive age-dependent Abeta deposition. In contrast, little or no C1q labeling was associated with diffuse or thioflavine-S negative Abeta deposits. Neurons in the hippocampus and entorhinal cortex, but less frequently in frontal cortex, were C1q positive in DS cases with sufficient neuropathology to have a diagnosis of Alzheimer's disease. C1q-positive neurons were associated with activated microglia. These results provide evidence for Abeta-mediated inflammatory factors contributing to the rapid accumulation of neuropathology in DS brain.<br /> (Copyright 2001 Academic Press.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Aging metabolism
Aging pathology
Alzheimer Disease metabolism
Alzheimer Disease pathology
Amyloid beta-Peptides immunology
Benzothiazoles
Brain metabolism
Brain pathology
Complement C1q immunology
Down Syndrome metabolism
Down Syndrome pathology
Encephalitis immunology
Encephalitis metabolism
Encephalitis pathology
Female
Humans
Immunohistochemistry
Male
Microglia immunology
Microglia metabolism
Microglia pathology
Middle Aged
Neurofibrillary Tangles immunology
Neurofibrillary Tangles metabolism
Neurofibrillary Tangles pathology
Neurons metabolism
Neurons pathology
Plaque, Amyloid immunology
Plaque, Amyloid metabolism
Plaque, Amyloid pathology
Thiazoles metabolism
Aging immunology
Alzheimer Disease immunology
Amyloid beta-Peptides metabolism
Brain immunology
Complement C1q metabolism
Down Syndrome immunology
Neurons immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0969-9961
- Volume :
- 8
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Neurobiology of disease
- Publication Type :
- Academic Journal
- Accession number :
- 11300721
- Full Text :
- https://doi.org/10.1006/nbdi.2000.0380