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[Gabapentin in 50 patients with epilepsy].
- Source :
-
Revista de neurologia [Rev Neurol] 2001 Jan 1-15; Vol. 32 (1), pp. 45-9. - Publication Year :
- 2001
-
Abstract
- Objective: To evaluate monotherapy treatment with the anticonvulsant drug gabapentin, its efficacy and tolerability when used in patients with partial and secondary generalized partial epileptic seizures of recent onset who had not received treatment or who, in spite of treatment with other antiepileptic drugs failed to attain control over their seizures.<br />Patients and Methods: We made an open prospective study of 50 patients diagnosed as having partial and secondarily generalized partial epileptic seizures. The patients were given treatment at their first visit and them regularly followed up for two years. Treatment was given progressively until a maintenance dose of 1.200 mg/day was reached, and the dose them adjusted individually.<br />Results: We included 50 patients in the study; 78% were treated with gabapentin. Ten percent stopped this treatment because it was ineffective. All the patients who continued their treatment with gabapentin had their seizures reduced by over 50%. This reduction in the number of seizures is statistically significant (p < 0.05) for patients with partial and secondarily generalized partial seizures. Twelve percent of the group of patients stopped their treatment because of side-effects.<br />Conclusions: When the results of our study are evaluated and compared with those published in the literature, it may be seen that gabapentin is a safe, effective drug which is well tolerated when used as monotherapy for the treatment of patients with partial seizures.
- Subjects :
- Acetates adverse effects
Adult
Anticonvulsants administration & dosage
Anticonvulsants adverse effects
Drug Evaluation
Drug Therapy, Combination
Epilepsies, Partial drug therapy
Epilepsy, Generalized drug therapy
Female
Follow-Up Studies
Gabapentin
Humans
Male
Patient Dropouts
Prospective Studies
Treatment Outcome
Acetates therapeutic use
Amines
Anticonvulsants therapeutic use
Cyclohexanecarboxylic Acids
Epilepsy drug therapy
gamma-Aminobutyric Acid
Subjects
Details
- Language :
- Spanish; Castilian
- ISSN :
- 0210-0010
- Volume :
- 32
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Revista de neurologia
- Publication Type :
- Academic Journal
- Accession number :
- 11293098