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Feeding colostrum, its composition and feeding duration variably modify proliferation and morphology of the intestine and digestive enzyme activities of neonatal calves.
- Source :
-
The Journal of nutrition [J Nutr] 2001 Apr; Vol. 131 (4), pp. 1256-63. - Publication Year :
- 2001
-
Abstract
- We studied the effects of amounts of colostrum consumed on intestinal morphology and proliferation and digestive enzyme activities in neonatal calves. Group GrCmax calves were fed colostrum from the first milking undiluted on d 1-3 and diluted with 25, 50, 75 and 75 parts of a milk replacer on d 4-7. Group GrC1-3 calves were fed colostrum from milkings 1-6 up to d 3 and then a milk replacer up to d 7. Group GrF1-3 calves were fed a milk-based formula (containing only traces of growth factors and hormones) up to d 3 and then a milk replacer up to d 7. Calves were killed on d 8. Differences in feeding affected villus sizes and villus height/crypt depth ratios in the duodenum (GrCmax > GrC1-3), villus areas and villus height/crypt depth ratios in the jejunum (GrC1-3 > GrF1-3) and crypt depths in the colon (GrF1-3 > GrC1-3). Furthermore, different feeding protocols affected the proliferation rates of epithelial cells in the duodenum (GrC1-3 > GrCmax; GrC1-3 > GrF1-3) and the jejunum (GrF1-3 > GrC1-3; based on Ki-67 labeling). Lipase activities in the pancreas were influenced by colostrum feeding (GrC(max) > GrC(1-3)). Colostrum intake differentially affected intestinal epithelial surface and proliferation and enzyme activities. Feeding high amounts of first colostrum seemed to enhance the survival of mature mucosal epithelial cells in selected parts of the small intestine, whereas the lack of colostrum seemed to decrease epithelial growth.
- Subjects :
- Animals
Animals, Newborn anatomy & histology
Body Weight
Cattle
Cell Division physiology
Colon anatomy & histology
Colon cytology
DNA metabolism
Health Status
Intestinal Mucosa cytology
Intestinal Mucosa metabolism
Intestine, Small anatomy & histology
Intestine, Small cytology
Intestines anatomy & histology
Jejunum enzymology
Male
Pancreas enzymology
Pancreas metabolism
Proteins metabolism
RNA metabolism
Time Factors
Animals, Newborn physiology
Colostrum chemistry
Diet
Digestion physiology
Enzymes metabolism
Intestines cytology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3166
- Volume :
- 131
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Journal of nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 11285335
- Full Text :
- https://doi.org/10.1093/jn/131.4.1256