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Acute adrenal failure associated with fluconazole after administration of high-dose cyclophosphamide.
- Source :
-
American journal of hematology [Am J Hematol] 2001 Apr; Vol. 66 (4), pp. 303-5. - Publication Year :
- 2001
-
Abstract
- A 63-year-old man received high-dose cyclophosphamide for peripheral blood stem-cell (PBSC) harvest. He received 200 mg fluconazole. On day 3, atrial fibrillation developed with blood pressure declining to 78 mmHg. The rapid adrenocorticotropin (ACTH) test showed blunted adrenal responses. He was suspected as having adrenal failure, and fluconazole was discontinued. The rapid ACTH test became normal on Day 14, and PBSCs were successfully harvested. To clarify the association between adrenal failure and fluconazole, we resumed 400 mg fluconazole on Day 16 and repeated the test on Day 21, which showed blunted adrenal responses. This case demonstrates that prophylactic use of fluconazole can cause adrenal insufficiency.<br /> (Copyright 2001 Wiley-Liss, Inc.)
- Subjects :
- Adrenal Insufficiency complications
Adrenocorticotropic Hormone
Antibiotic Prophylaxis
Antifungal Agents therapeutic use
Antineoplastic Agents, Alkylating administration & dosage
Atrial Fibrillation etiology
Candidiasis complications
Candidiasis drug therapy
Cyclophosphamide administration & dosage
Fluconazole therapeutic use
Hematopoietic Stem Cell Transplantation
Humans
Immunocompromised Host
Male
Middle Aged
Multiple Myeloma complications
Adrenal Insufficiency chemically induced
Antifungal Agents adverse effects
Antineoplastic Agents, Alkylating adverse effects
Cyclophosphamide adverse effects
Fluconazole adverse effects
Hematopoietic Stem Cell Mobilization adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0361-8609
- Volume :
- 66
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- American journal of hematology
- Publication Type :
- Academic Journal
- Accession number :
- 11279645
- Full Text :
- https://doi.org/10.1002/ajh.1063