Back to Search
Start Over
Response to high-dose intravenous immune globulin as a valuable factor predicting the effect of splenectomy in chronic idiopathic thrombocytopenic purpura patients.
- Source :
-
American journal of hematology [Am J Hematol] 2001 Mar; Vol. 66 (3), pp. 197-202. - Publication Year :
- 2001
-
Abstract
- This study was conducted to verify whether the response to high-dose intravenous immune globulin (IVIG) was related to the effect of splenectomy in chronic idiopathic thrombocytopenic purpura (ITP) patients. A total of 79 patients over 16 years of age were enrolled in this study. The response to the treatment was classified on the basis of the platelet count as no response (NR, <50 x 10(9)/l), incomplete response (IR, (50-150) x 10(9)/l), and complete response (CR, >150 x 10(9)/l). The response was evaluated after the infusion of high-dose IVIG, within 2 weeks after splenectomy (immediate response), and during a follow-up period of more than 6 months after splenectomy (sustained response), respectively. 58 patients (73.4%) showed responses (CR or IR) to high-dose IVIG. After splenectomy, immediate responses were observed in 73 patients (92%). The response to high-dose IVIG had no relationship with the immediate response to splenectomy (P = 0.333). A follow-up evaluation was possible with 58 patients; 6 patients with NR in immediate responses did not show any response during the follow-up period, and 17 patients relapsed within 6 months after immediate responses, so 35 patients (60.3%) had sustained responses. Responders to IVIG had significantly higher sustained response rates to splenectomy than non-responders (62% vs. 38%, P = 0.001). These results indicate that the response to high-dose IVIG could be a valuable factor predicting the sustained response to splenectomy in chronic ITP patients.
- Subjects :
- Adult
Aged
Combined Modality Therapy
Female
Humans
Immunoglobulins, Intravenous therapeutic use
Male
Middle Aged
Platelet Count
Recurrence
Retrospective Studies
Time Factors
Treatment Outcome
Immunoglobulins, Intravenous administration & dosage
Purpura, Thrombocytopenic, Idiopathic drug therapy
Purpura, Thrombocytopenic, Idiopathic surgery
Splenectomy
Subjects
Details
- Language :
- English
- ISSN :
- 0361-8609
- Volume :
- 66
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- American journal of hematology
- Publication Type :
- Academic Journal
- Accession number :
- 11279626
- Full Text :
- https://doi.org/10.1002/1096-8652(200103)66:3<197::aid-ajh1044>3.0.co;2-6