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The inhibition of the transplacental blastomogenic effect of nitrosomethylurea by postnatal administration of buformin to rats.
- Source :
-
Carcinogenesis [Carcinogenesis] 1980; Vol. 1 (12), pp. 975-8. - Publication Year :
- 1980
-
Abstract
- N-Nitrosomethylurea (NMU) (20 mg/kg) was i.p. administered to rats on the 21st day of pregnancy. A decrease of glucose utilisation in the oral glucose tolerance test was found in 3 month old female progeny of NMU-treated rats. The serum insulin level did not differ from control, but serum cholesterol level was higher in offspring of NMU-treated rats. The ability of diethylstilboestrol to inhibit compensatory ovarian hypertrophy was decreased in female hemicastrated 3 month old rats whose mothers were treated with NMU. Postnatal administration of the antidiabetic drug buformin decreased the malignant neurogenic tumor incidence 3.5 times (to rats transplacentally treated with NMU).
- Subjects :
- Animals
Buformin administration & dosage
Buformin pharmacology
Cholesterol blood
Dietary Carbohydrates pharmacokinetics
Diethylstilbestrol pharmacology
Energy Metabolism drug effects
Female
Glucose Tolerance Test
Hypertrophy
Hypoglycemic Agents administration & dosage
Hypoglycemic Agents pharmacology
Hypothalamo-Hypophyseal System physiopathology
Insulin blood
Kidney Neoplasms chemically induced
Kidney Neoplasms embryology
Kidney Neoplasms prevention & control
Male
Maternal-Fetal Exchange
Neoplasms, Experimental chemically induced
Neoplasms, Experimental embryology
Neoplasms, Nerve Tissue chemically induced
Neoplasms, Nerve Tissue embryology
Neoplasms, Nerve Tissue prevention & control
Nervous System Neoplasms chemically induced
Nervous System Neoplasms embryology
Nervous System Neoplasms prevention & control
Ovariectomy
Ovary drug effects
Ovary pathology
Pregnancy
Prenatal Exposure Delayed Effects
Rats
Somatomedins deficiency
Buformin therapeutic use
Diethylstilbestrol analogs & derivatives
Hypoglycemic Agents therapeutic use
Methylnitrosourea toxicity
Neoplasms, Experimental prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 0143-3334
- Volume :
- 1
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Carcinogenesis
- Publication Type :
- Academic Journal
- Accession number :
- 11272113
- Full Text :
- https://doi.org/10.1093/carcin/1.12.975