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Glucose metabolism in liver transplant recipients treated with FK 506 or cyclosporin in the European multicentre study.
- Source :
-
Transplant international : official journal of the European Society for Organ Transplantation [Transpl Int] 1994; Vol. 7 Suppl 1, pp. S11-4. - Publication Year :
- 1994
-
Abstract
- From September 1990 to January 1992, 545 liver transplant patients were randomised to treatment with either FK506 and prednisolone or a conventional cyclosporin-based immunosuppressive regimen (CBIR). Eight European centres participated in the study. Adverse events were reported as defined by each centre. Hyperglycaemia was reported as an adverse event in 30.7% of patients receiving FK 506 compared with 20.5% in the CBIR group (P < 0.01). Diabetes mellitus was reported in 17.2% of patients treated with FK 506 and 9.5% of CBIR-treated patients (P < 0.05). Treatment with insulin was required in 12.0% of patients in the DK 506 treatment group and in 5% in the CBIR group at 6 months. Initially, higher doses of FK 506 were used. During the study, the protocol was changed to allow a lower dose of FK 506. When the early and late cohorts of patients were compared, the incidence of diabetes mellitus fell from 23.9% to 10.5% in FK 506-treated patients but remained relatively constant in the CBIR group (10.4% to 8.7%). The median cumulative doses of i.v. and p.o. corticosteroids were significantly greater in the CBIR group. Thus, in the overall series, the incidence of diabetes mellitus was significantly greater in the FK 506 group as compared with the CBIR group. However, when a lower FK 506 dose was used during the second half of the study, the difference in the incidence of diabetes mellitus disappeared.
- Subjects :
- Adolescent
Adult
Aged
Blood Glucose metabolism
Cyclosporine adverse effects
Drug Therapy, Combination
Europe
Female
Humans
Hyperglycemia chemically induced
Immunosuppressive Agents adverse effects
Liver Transplantation physiology
Male
Middle Aged
Tacrolimus adverse effects
Time Factors
Cyclosporine therapeutic use
Glucose metabolism
Immunosuppressive Agents therapeutic use
Liver Transplantation immunology
Tacrolimus therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0934-0874
- Volume :
- 7 Suppl 1
- Database :
- MEDLINE
- Journal :
- Transplant international : official journal of the European Society for Organ Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 11271178
- Full Text :
- https://doi.org/10.1111/j.1432-2277.1994.tb01302.x