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Synthetic analogues of SB-219383. Novel C-glycosyl peptides as inhibitors of tyrosyl tRNA synthetase.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2001 Mar 12; Vol. 11 (5), pp. 711-4. - Publication Year :
- 2001
-
Abstract
- Novel inhibitors of bacterial tyrosyl tRNA synthetase have been synthesised in which the cyclic hydroxylamine moiety of SB-219383 is replaced by C-pyranosyl derivatives. Potent and selective inhibition of bacterial tyrosyl tRNA synthetase was obtained.
- Subjects :
- Bacterial Proteins chemistry
Bacterial Proteins metabolism
Bridged Bicyclo Compounds, Heterocyclic pharmacology
Enzyme Inhibitors pharmacology
Furans pharmacology
Models, Molecular
Molecular Structure
Staphylococcus aureus enzymology
Staphylococcus aureus metabolism
Bridged Bicyclo Compounds, Heterocyclic chemistry
Enzyme Inhibitors chemistry
Furans chemistry
Pyrans chemistry
Tyrosine-tRNA Ligase antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 11
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 11266175
- Full Text :
- https://doi.org/10.1016/s0960-894x(01)00039-7