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Platelet glycoprotein IIb/IIIa inhibitors combined with fibrinolytic agents to treat acute myocardial infarction.
- Source :
-
Journal of thrombosis and thrombolysis [J Thromb Thrombolysis] 2001 Feb; Vol. 11 (1), pp. 83-91. - Publication Year :
- 2001
-
Abstract
- Fibrinolytic drugs given within 6-12 h of onset of symptoms have reduced mortality by approximately 30%. However, even the most efficacious regimens are associated with only a 55% reperfusion rate at 90 min. In contrast, primary angioplasty (without fibrinolysis) yields to reperfusion in 75-95% of cases. This therapy, when compared with fibrinolysis, is associated with lower early mortality and reinfarction rates. Therefore, there is a need to find a therapy that would have the speed and ease of administration of intravenous lysis and the efficacy of primary angioplasty in re-establishing normal myocardial tissue perfusion. This article will review the rationale for the use of partial-dose lytic agents combined with platelet glycoprotein IIb/IIIa inhibitors for the treatment of acute myocardial infarction. The available and upcoming data on this subject will also be reviewed.
Details
- Language :
- English
- ISSN :
- 0929-5305
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of thrombosis and thrombolysis
- Publication Type :
- Academic Journal
- Accession number :
- 11248791
- Full Text :
- https://doi.org/10.1023/a:1008948025215