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Influence of cyclic intravenous pamidronate on proinflammatory monocytic cytokine profiles and bone density in rheumatoid arthritis treated with low dose prednisolone and methotrexate.
- Source :
-
Clinical and experimental rheumatology [Clin Exp Rheumatol] 2001 Jan-Feb; Vol. 19 (1), pp. 13-20. - Publication Year :
- 2001
-
Abstract
- Objectives: The aim of this work was to evaluate in a randomised double-blind prospective study the effect of pamidronate on intracellular monocytic cytokine profiles (IL-1, IL-6, TNF-alpha) and bone density in rheumatoid arthritis patients.<br />Methods: Twenty rheumatoid arthritis patients were treated for one year with methotrexate and a low dose of prednisolone. Double blind randomisation was performed for either i.v. pamidronate (at 3-month intervals) or placebo. The effect of pamidronate was evaluated on intracellular cytokine profiles (IL-1, IL-6, TNF-alpha), disease activity and bone mass measurements. The human monocytic cell line THP-1 was used to evaluate in vitro apoptosis by pamidronate.<br />Results: Spontaneous production of interleukin-1 beta by patient blood monocytes was lower in the pamidronate group and was associated with an increase in bone density of the spine after 12 months of therapy. In vitro a dose-related increase in pamidronate induced apoptosis was found in THP-1 cells.<br />Conclusions: This prospective double-blind randomised study demonstrated that pamidronate therapy resulted in an increase of bone density despite treatment with steroids. This rise is associated with a suppression of interleukin-1 beta production in monocytes of patients treated with pamidronate. Our in vitro experiments suggest that this anti-inflammatory effect could be due to an increase in the apoptosis of monocytic cells.
- Subjects :
- Adult
Aged
Blood Sedimentation drug effects
C-Reactive Protein drug effects
Diphosphonates pharmacology
Diphosphonates therapeutic use
Double-Blind Method
Drug Interactions
Female
Humans
Injections, Intravenous
Male
Methotrexate pharmacology
Middle Aged
Pamidronate
Prednisolone pharmacology
Prednisolone therapeutic use
Prospective Studies
Random Allocation
Anti-Inflammatory Agents pharmacology
Anti-Inflammatory Agents therapeutic use
Apoptosis drug effects
Arthritis, Rheumatoid drug therapy
Bone Density drug effects
Cytokines drug effects
Immunosuppressive Agents pharmacology
Monocytes drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0392-856X
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Clinical and experimental rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 11247319