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Bonzo/CXCR6 expression defines type 1-polarized T-cell subsets with extralymphoid tissue homing potential.
- Source :
-
The Journal of clinical investigation [J Clin Invest] 2001 Mar; Vol. 107 (5), pp. 595-601. - Publication Year :
- 2001
-
Abstract
- Chemokine receptor expression is finely controlled during T-cell development. We show that newly identified chemokine receptor Bonzo/CXCR6 is expressed by subsets of Th1 or T-cytotoxic 1 (Tc1) cells, but not by Th2 or Tc2 cells, establishing Bonzo as a differential marker of polarized type 1 T cells in vitro and in vivo. Priming of naive T cells by dendritic cells induces expression of Bonzo on T cells. IL-12 enhances this dendritic cell-dependent upregulation, while IL-4 inhibits it. In blood, 35-56% of Bonzo+ CD4 T cells are Th1 cells, and 60-65% of Bonzo+ CD8 T cells are Tc1 cells, while few Bonzo+ cells are type 2 T cells. Almost all Bonzo+ Tc1 cells contain preformed granzyme A and display cytotoxic effector phenotype. Most Bonzo+ T cells lack L-selectin and/or CCR7, homing receptors for lymphoid tissues. Instead, Bonzo+ T cells are dramatically enriched among T cells in tissue sites of inflammation, such as rheumatoid joints and inflamed livers. Bonzo may be important in trafficking of effector T cells that mediate type 1 inflammation, making it a potential target for therapeutic modulation of inflammatory diseases.
- Subjects :
- Arthritis immunology
Cell Differentiation
Cells, Cultured
Cytokines pharmacology
Dendritic Cells immunology
Gene Expression drug effects
Humans
Immunologic Memory
Liver immunology
Liver Cirrhosis immunology
Lymphocyte Subsets classification
Lymphocyte Subsets immunology
Receptors, CXCR6
Receptors, Chemokine
Receptors, Lymphocyte Homing metabolism
Synovial Fluid immunology
T-Lymphocytes, Cytotoxic immunology
Th1 Cells immunology
Inflammation immunology
Receptors, Cytokine metabolism
Receptors, G-Protein-Coupled
Receptors, Virus
T-Lymphocytes, Cytotoxic classification
Th1 Cells classification
Subjects
Details
- Language :
- English
- ISSN :
- 0021-9738
- Volume :
- 107
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of clinical investigation
- Publication Type :
- Academic Journal
- Accession number :
- 11238560
- Full Text :
- https://doi.org/10.1172/JCI11902