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Refractive changes caused by hypoxia after laser in situ keratomileusis surgery.

Authors :
Nelson ML
Brady S
Mader TH
White LJ
Parmley VC
Winkle RK
Source :
Ophthalmology [Ophthalmology] 2001 Mar; Vol. 108 (3), pp. 542-4.
Publication Year :
2001

Abstract

Objective: To determine whether hypoxia induces refractive changes in subjects who have had laser in situ keratomileusis (LASIK) refractive surgery.<br />Design: Prospective paired eye clinical trial.<br />Participants: There were 20 LASIK subjects (40 eyes) and 20 myopic non-LASIK controls (40 eyes).<br />Intervention: Each subject had one eye exposed to ocular surface hypoxia (humidified nitrogen) by use of an airtight goggle system at sea level for 2 hours. The other eye was simultaneously exposed to humidified, compressed air (21% oxygen) with the same airtight goggle system.<br />Main Outcome Measures: Keratometry, cycloplegic refraction, and pachymetry were compared before and after exposure by use of repeated measures analysis of variance.<br />Results: A significant myopic shift (P: < 0.01) occurred in LASIK corneas exposed to hypoxia compared with myopic control subjects. A significant increase in corneal thickening occurred symmetrically in both LASIK and control subjects exposed to hypoxia. There was a trend toward corneal steepening (keratometry) in LASIK subjects, but this was not statistically significant.<br />Conclusions: These results suggest that ocular surface hypoxia induces a myopic shift in LASIK subjects.

Details

Language :
English
ISSN :
0161-6420
Volume :
108
Issue :
3
Database :
MEDLINE
Journal :
Ophthalmology
Publication Type :
Academic Journal
Accession number :
11237908
Full Text :
https://doi.org/10.1016/s0161-6420(00)00592-3