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The physical maps for sequencing human chromosomes 1, 6, 9, 10, 13, 20 and X.
- Source :
-
Nature [Nature] 2001 Feb 15; Vol. 409 (6822), pp. 942-3. - Publication Year :
- 2001
-
Abstract
- We constructed maps for eight chromosomes (1, 6, 9, 10, 13, 20, X and (previously) 22), representing one-third of the genome, by building landmark maps, isolating bacterial clones and assembling contigs. By this approach, we could establish the long-range organization of the maps early in the project, and all contig extension, gap closure and problem-solving was simplified by containment within local regions. The maps currently represent more than 94% of the euchromatic (gene-containing) regions of these chromosomes in 176 contigs, and contain 96% of the chromosome-specific markers in the human gene map. By measuring the remaining gaps, we can assess chromosome length and coverage in sequenced clones.
Details
- Language :
- English
- ISSN :
- 0028-0836
- Volume :
- 409
- Issue :
- 6822
- Database :
- MEDLINE
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- 11237015
- Full Text :
- https://doi.org/10.1038/35057165