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Plastic membrane electrode for the potentiometric determination of pethidine hydrochloride in pharmaceutical preparations.
- Source :
-
Fresenius' journal of analytical chemistry [Fresenius J Anal Chem] 2000 Oct; Vol. 368 (4), pp. 335-7. - Publication Year :
- 2000
-
Abstract
- A novel poly(vinyl chloride) membrane electrode with dibutyl phthalate as plasticizer based on the pethidine-tetraphenylborate ion-association complex as ion-exchange site for the determination of pethidine hydrochloride in injections and tablets was developed. A linear response for 1 x 10(-5) to 1 x 10(-2) mol/L drug with a slope of 51.77 mV/decade was established. The optimum pH range was 2-8. The lower detection limit was 2.18 x 10(-6) mol/L. There were negligible interferences from a number of inorganic and organic cations and some common drug excipients. The electrode proposed had been successfully applied to determine pethidine hydrochloride in tablets and injections. The results correlated well with those obtained by the United States Pharmacopoeia standard procedure.
- Subjects :
- Calibration
Electrochemistry
Electrodes
Hydrogen-Ion Concentration
Injections
Ions adverse effects
Membranes, Artificial
Meperidine standards
Pharmaceutical Preparations standards
Polyvinyl Chloride chemistry
Potentiometry
Reproducibility of Results
Sensitivity and Specificity
Tablets analysis
Meperidine analysis
Pharmaceutical Preparations analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0937-0633
- Volume :
- 368
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Fresenius' journal of analytical chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 11227500
- Full Text :
- https://doi.org/10.1007/s002160000463