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Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2001 Feb 27; Vol. 98 (5), pp. 2306-11. Date of Electronic Publication: 2001 Feb 13. - Publication Year :
- 2001
-
Abstract
- Using a consensus sequence in inositol phosphate kinase, we have identified and cloned a 44-kDa mammalian inositol phosphate kinase with broader catalytic capacities than any other member of the family and which we designate mammalian inositol phosphate multikinase (mIPMK). By phosphorylating inositol 4,5-bisphosphate, mIPMK provides an alternative biosynthesis for inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)]. mIPMK also can form the pyrophosphate disphosphoinositol tetrakisphosphate (PP-InsP(4)) from InsP(5). Additionally, mIPMK forms InsP(4) from Ins(1,4,5)P(3) and InsP(5) from Ins(1,3,4,5)P(4).
- Subjects :
- Amino Acid Sequence
Animals
Base Sequence
Cloning, Molecular
DNA Primers
In Situ Hybridization
Male
Molecular Sequence Data
Phosphotransferases (Alcohol Group Acceptor) chemistry
Phosphotransferases (Alcohol Group Acceptor) genetics
Rats
Rats, Sprague-Dawley
Sequence Homology, Amino Acid
Inositol 1,4,5-Trisphosphate biosynthesis
Phosphotransferases (Alcohol Group Acceptor) metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0027-8424
- Volume :
- 98
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 11226235
- Full Text :
- https://doi.org/10.1073/pnas.041614598