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Detection of false-negative Pap smears using the PAPNET system.

Authors :
Troni GM
Cipparrone I
Cariaggi MP
Ciatto S
Miccinesi G
Zappa M
Confortini M
Source :
Tumori [Tumori] 2000 Nov-Dec; Vol. 86 (6), pp. 455-7.
Publication Year :
2000

Abstract

Aims and Background: False-negative cytological diagnoses represent the critical point of a screening program for early detection of cervical cancer. Computer-assisted reading using neural network technology has been suggested as a possible approach to manage the problem. The study assessed the performance and the cost-outcome ratio of computer-assisted versus conventional manual Pap smear reading.<br />Methods: One thousand routine smears, seeded with 81 false-negative smears, were independently interpreted by two readers by conventional and PAPNET-assisted reading. Results of both readings were compared in terms of: a)sensitivity for false-negative smears, b)specificity, and c) cost-outcome (cost per CIN2+ lesion detected).<br />Results: PAPNET-assisted reading showed a small increase in sensitivity only for one reader. Including the cost of PAPNET, the cost per detected lesion would be $7,543 and the cost per additional detected lesion would be $25,748.<br />Conclusions: The present study provides further evidence that PAPNET-assisted screening may allow the detection of a few extra cases of CIN2+ lesions with respect to conventional reading, though at a very high cost.

Details

Language :
English
ISSN :
0300-8916
Volume :
86
Issue :
6
Database :
MEDLINE
Journal :
Tumori
Publication Type :
Academic Journal
Accession number :
11218185
Full Text :
https://doi.org/10.1177/030089160008600604