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Detection of false-negative Pap smears using the PAPNET system.
- Source :
-
Tumori [Tumori] 2000 Nov-Dec; Vol. 86 (6), pp. 455-7. - Publication Year :
- 2000
-
Abstract
- Aims and Background: False-negative cytological diagnoses represent the critical point of a screening program for early detection of cervical cancer. Computer-assisted reading using neural network technology has been suggested as a possible approach to manage the problem. The study assessed the performance and the cost-outcome ratio of computer-assisted versus conventional manual Pap smear reading.<br />Methods: One thousand routine smears, seeded with 81 false-negative smears, were independently interpreted by two readers by conventional and PAPNET-assisted reading. Results of both readings were compared in terms of: a)sensitivity for false-negative smears, b)specificity, and c) cost-outcome (cost per CIN2+ lesion detected).<br />Results: PAPNET-assisted reading showed a small increase in sensitivity only for one reader. Including the cost of PAPNET, the cost per detected lesion would be $7,543 and the cost per additional detected lesion would be $25,748.<br />Conclusions: The present study provides further evidence that PAPNET-assisted screening may allow the detection of a few extra cases of CIN2+ lesions with respect to conventional reading, though at a very high cost.
- Subjects :
- Female
Humans
Italy
Predictive Value of Tests
Prospective Studies
Sensitivity and Specificity
Uterine Cervical Neoplasms economics
False Negative Reactions
Medical Records Systems, Computerized statistics & numerical data
Papanicolaou Test
Uterine Cervical Neoplasms diagnosis
Uterine Cervical Neoplasms prevention & control
Vaginal Smears economics
Vaginal Smears statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 0300-8916
- Volume :
- 86
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Tumori
- Publication Type :
- Academic Journal
- Accession number :
- 11218185
- Full Text :
- https://doi.org/10.1177/030089160008600604