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Using phylogenetic analysis to trace HIV-1 migration among western European injecting drug users seroconverting from 1984 to 1997.
- Source :
-
AIDS (London, England) [AIDS] 2001 Jan 26; Vol. 15 (2), pp. 257-66. - Publication Year :
- 2001
-
Abstract
- Objective: To reconstruct the epidemiological relationships of the HIV epidemics among injecting drug users (IDU) in western Europe.<br />Methods: HIV env V3 sequences of and epidemiological data were obtained from 145 IDU who seroconverted in three sequential periods: 1984-1988, 1989-1992 and 1993-1997. The sequences were phylogenetically analysed and examined for signature patterns characteristic of northern European IDU, including the conserved GGC codon in the V3 loop.<br />Results: Subpopulations of genetically related HIV strains were observed in Italy, France, Scotland and Spain, in contrast to the Netherlands, Austria and Switzerland. This difference between the two groups of countries suggests that the HIV epidemics amongst IDU in the latter group was caused by multiple virus introductions. In Edinburgh and the surrounding area, most IDU were infected with the same GGC strain over the 12-year study period. The epidemic among IDU in north-western Europe started with GGC viruses, whereas in south-western Europe non-GGC viruses predominated. This geographical separation has faded during the course of the epidemic, most likely because of virus exchange among IDU populations.
- Subjects :
- Base Sequence
DNA, Viral
Disease Transmission, Infectious
Europe epidemiology
Genetic Variation
HIV Envelope Protein gp120 classification
HIV Seropositivity complications
HIV Seropositivity epidemiology
HIV Seropositivity virology
HIV-1 genetics
Humans
Molecular Sequence Data
Peptide Fragments classification
Phylogeny
Prospective Studies
Disease Outbreaks
HIV Envelope Protein gp120 genetics
HIV Seropositivity transmission
HIV-1 classification
Peptide Fragments genetics
Substance Abuse, Intravenous complications
Subjects
Details
- Language :
- English
- ISSN :
- 0269-9370
- Volume :
- 15
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- AIDS (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 11216936
- Full Text :
- https://doi.org/10.1097/00002030-200101260-00017