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Parameters of microsomal and cytosolic liver function but not of liver perfusion predict portal vein velocity in noncirrhotic patients with chronic hepatitis C.
- Source :
-
Digestive diseases and sciences [Dig Dis Sci] 2000 Nov; Vol. 45 (11), pp. 2233-7. - Publication Year :
- 2000
-
Abstract
- Our aim was to compare color-coded Doppler sonography (CCDS) and quantitative testing of liver function (QTLF) in patients with chronic hepatitis C. In all, 74 patients with chronic hepatitis C and mild fibrosis underwent QTLF, which included aminopyrine breath test (ABT), galactose elimination capacity (GEC), sorbitol clearance (SC), and indocyanine green clearance (ICG). Hepatic artery velocity and resistance index (HA-V, HA-RI) as well as portal vein velocity (PV-V) were measured by CCDS. ABT, GEC, and PV-V were significantly reduced, whereas SC1, ICG, HA-V, and HA-RI showed normal levels. There was a significant correlation between reduction in PV-V only with GEC and ABT. QTLF did not correlate with HA-V and HA-RI. In conclusion, in hepatitis C patients with liver fibrosis, ABT and GEC are decreased significantly, which was paralleled by a reduction of PV-V. Unexpectedly SC1 and ICG, the classical hepatic perfusion parameters, do not correlate with the parameters measured by CCDS.
- Subjects :
- Aged
Aminopyrine
Blood Flow Velocity physiology
Breath Tests
Female
Galactose
Hepatitis C, Chronic physiopathology
Humans
Indocyanine Green
Liver Function Tests
Male
Metabolic Clearance Rate physiology
Middle Aged
Prospective Studies
Sorbitol
Cytosol physiology
Hepatitis C, Chronic diagnostic imaging
Microsomes, Liver physiology
Portal Vein diagnostic imaging
Ultrasonography, Doppler, Color
Subjects
Details
- Language :
- English
- ISSN :
- 0163-2116
- Volume :
- 45
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Digestive diseases and sciences
- Publication Type :
- Academic Journal
- Accession number :
- 11215745
- Full Text :
- https://doi.org/10.1023/a:1026600921967