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Effect of biliary stasis and hepatotoxins on the excretion of iopanoate in the rat.
- Source :
-
The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 1975 Mar; Vol. 192 (3), pp. 618-29. - Publication Year :
- 1975
-
Abstract
- In rats, hepatic dysfunction was induced with CCl4, SKF 525-A, taurolithocholic acid and alpha-naphthylisothiocyanate and by acute and chronic surgical ligation of the bile duct. Biliary and urinary excretion of 125I-labeled iopanoate was measured after a standard i.v. dose. In the absence of normal biliary excretion, the amount excreted in the urine varied over a wide range (0.25-11.2 percent of the dose), with highest rates of urinary excretion occurring after alpha-naphthylisothiocyanate and chronic stasis. Drug disposition was further determined by tissue analysis of liver and kidney. The results indicate that, for a drug that is normally almost exclusively excreted by the bile, in the presence of hepatic dysfunction the amount excreted by the alternate urinary route depends on the type of the induced hepatic disorder. The intrarenal distribution of 125I-radioactivity is strongly influenced by its plasma concentration rather than just by the rate of excretion in the urine.
- Subjects :
- Animals
Bile Ducts physiology
Carbon Tetrachloride Poisoning metabolism
Chemical and Drug Induced Liver Injury physiopathology
Cholestasis physiopathology
Glomerular Filtration Rate
Glucuronates metabolism
Iodine Radioisotopes
Kidney metabolism
Kinetics
Lithocholic Acid analogs & derivatives
Lithocholic Acid poisoning
Male
Naphthalenes poisoning
Proadifen poisoning
Rats
Taurocholic Acid analogs & derivatives
Taurocholic Acid poisoning
Thiocyanates poisoning
Chemical and Drug Induced Liver Injury metabolism
Cholestasis metabolism
Iopanoic Acid metabolism
Liver metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3565
- Volume :
- 192
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of pharmacology and experimental therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 1120959