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Tau protein in cerebrospinal fluid (CSF): a blood-CSF barrier related evaluation in patients with various neurological diseases.
- Source :
-
Neuroscience letters [Neurosci Lett] 2001 Mar 09; Vol. 300 (2), pp. 95-8. - Publication Year :
- 2001
-
Abstract
- Tau protein (tau) is primarily localised in neurons, and after brain parenchymal damage its release into cerebrospinal fluid (CSF) is increased. The particular influences of blood-CSF barrier function and of disease topography on CSF tau levels have not been studied yet. CSF tau concentrations determined by enzyme-immunoassay in various neurological diseases (n = 61) were not dependent upon blood-CSF barrier dysfunction. Significant elevation of tau levels in patients with meningoencephalitis and cerebral hemorrhage indicates brain parenchymal damage. In contrast, tau levels remained normal in patients with bacterial meningitis if encephalitic complications did not occur. In patients with Guillain-Barré syndrome tau levels were low. Increased tau levels in active multiple sclerosis compared to clinically nonactive states indicate axonal pathology in active disease.
- Subjects :
- Albumins cerebrospinal fluid
Biomarkers cerebrospinal fluid
Brain pathology
Brain physiopathology
Brain Diseases physiopathology
Cerebrovascular Disorders cerebrospinal fluid
Cerebrovascular Disorders physiopathology
Diagnosis, Differential
Encephalitis cerebrospinal fluid
Encephalitis physiopathology
Humans
Meningitis, Bacterial cerebrospinal fluid
Meningitis, Bacterial diagnosis
Meningitis, Bacterial physiopathology
Multiple Sclerosis cerebrospinal fluid
Multiple Sclerosis physiopathology
Nerve Degeneration pathology
Nerve Degeneration physiopathology
Neurons pathology
Blood-Brain Barrier physiology
Brain metabolism
Brain Diseases cerebrospinal fluid
Nerve Degeneration metabolism
Neurons metabolism
tau Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0304-3940
- Volume :
- 300
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Neuroscience letters
- Publication Type :
- Academic Journal
- Accession number :
- 11207383
- Full Text :
- https://doi.org/10.1016/s0304-3940(01)01556-7