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2,4-Disubstituted oxazoles and thiazoles as latent pharmacophores for diacylhydrazine of SC-51089, a potent PGE2 antagonist.
- Source :
-
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2001 Jan; Vol. 9 (1), pp. 1-6. - Publication Year :
- 2001
-
Abstract
- 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[1-oxo-3-(4-pyridinyl)propyl]hydrazide, monohydrochloride (1, SC-51089) is a functional PGE2 antagonist selective for the EP1 receptor subtype with antinociceptive activity. Analogues of SC-51089, in which the diacylhydrazine moiety has been replaced with 2,4-disubstituted-oxazoles and-thiazoles, are described.
Details
- Language :
- English
- ISSN :
- 0968-0896
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 11197330
- Full Text :
- https://doi.org/10.1016/s0968-0896(00)00229-7