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Chemotherapy-induced unconjugated hyperbilirubinemia caused by a mutation of the bilirubin uridine-5'-diphosphate-glucuronosyltransferase gene.

Authors :
Maruo Y
Sato H
Bamba N
Iwai M
Sawa H
Fujino H
Taga T
Ota S
Shimada M
Source :
Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2001 Jan; Vol. 23 (1), pp. 45-7.
Publication Year :
2001

Abstract

Chemotherapy for malignant neoplasms sometimes causes unconjugated hyperbilirubinemia in the absence of liver dysfunction. We analyzed the association of chemotherapy-induced hyperbilirubinemia with mutations of the bilirubin uridine-5'-diphosphate (UDP)-glucuronosyltransferase gene (UGT1A1) from two leukemic patients in whom chemotherapy resulted in a hyperbilirubinemic response. We isolated genomic DNA from peripheral blood samples and amplified UGT1A1 by polymerase chain reaction. The amplified DNA fragments were analyzed by direct sequencing. The genes of the two patients revealed an identical heterozygous missense mutation in exon 1 (211G-->A: G71R). This UGT1A1 mutation may be the basis of chemotherapy-induced unconjugated hyperbilirubinemia.

Details

Language :
English
ISSN :
1077-4114
Volume :
23
Issue :
1
Database :
MEDLINE
Journal :
Journal of pediatric hematology/oncology
Publication Type :
Academic Journal
Accession number :
11196269
Full Text :
https://doi.org/10.1097/00043426-200101000-00010