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Chemotherapy-induced unconjugated hyperbilirubinemia caused by a mutation of the bilirubin uridine-5'-diphosphate-glucuronosyltransferase gene.
- Source :
-
Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2001 Jan; Vol. 23 (1), pp. 45-7. - Publication Year :
- 2001
-
Abstract
- Chemotherapy for malignant neoplasms sometimes causes unconjugated hyperbilirubinemia in the absence of liver dysfunction. We analyzed the association of chemotherapy-induced hyperbilirubinemia with mutations of the bilirubin uridine-5'-diphosphate (UDP)-glucuronosyltransferase gene (UGT1A1) from two leukemic patients in whom chemotherapy resulted in a hyperbilirubinemic response. We isolated genomic DNA from peripheral blood samples and amplified UGT1A1 by polymerase chain reaction. The amplified DNA fragments were analyzed by direct sequencing. The genes of the two patients revealed an identical heterozygous missense mutation in exon 1 (211G-->A: G71R). This UGT1A1 mutation may be the basis of chemotherapy-induced unconjugated hyperbilirubinemia.
- Subjects :
- Adolescent
Child
Female
Humans
Hyperbilirubinemia genetics
Male
Polymerase Chain Reaction
Antineoplastic Combined Chemotherapy Protocols adverse effects
Glucuronosyltransferase genetics
Hyperbilirubinemia chemically induced
Leukemia, Myeloid, Acute drug therapy
Mutation, Missense
Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1077-4114
- Volume :
- 23
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of pediatric hematology/oncology
- Publication Type :
- Academic Journal
- Accession number :
- 11196269
- Full Text :
- https://doi.org/10.1097/00043426-200101000-00010