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Increased incidence of autoantibodies to interleukin-1a in rheumatoid arthritis with interstitial lung disease.
- Source :
-
Respirology (Carlton, Vic.) [Respirology] 2000 Dec; Vol. 5 (4), pp. 315-20. - Publication Year :
- 2000
-
Abstract
- Objective: To clarify the clinical significance of autoantibodies (auto-Ab) to interleukin-1alpha (IL-1alpha) in rheumatoid arthritis (RA) with interstitial lung disease (ILD), we examined the IL-1alpha auto-Ab level in serum of patients with RA with/without ILD.<br />Methodology: We investigated the level of IL-1alpha auto-Ab in serum of 70 patients with RA with/without ILD and 40 control patients (CP). Levels of IL-1alpha auto-Ab were measured by radioimmunoassay, and serum was regarded as IL-1alpha auto-Ab positive at an auto-Ab level of more than 5 ng/mL.<br />Results: Interleukin-1alpha auto-Ab was detected in the serum of 30 out of 70 RA patients (42.9%), and six out of 40 CP (15%) (P < 0.05). Interleukin-1alpha auto-Ab were detected in the serum of 18 out of 32 patients with RA with ILD (56.2%) and 12 out of 38 patients with RA without ILD (31.5%). The positive rate of these autoantibodies in RA with ILD was significantly higher than that in RA without ILD (P < 0.05). Although C-reactive protein, immunoglobulin G, rheumatoid factor and rheumatoid arthritis particle agglutination levels in serum from patients with RA with ILD were not significantly different between the IL-1alpha auto-Ab-positive and -negative groups, the lactate dehydrogenase level (LDH) and AaDO, in the IL-1alpha auto-Ab-positive group were significantly higher than those in the negative group (LDH: P < 0.001, AaDO2: P < 0.05).<br />Conclusion: These results suggest that IL-1alpha auto-Ab are generated in response to the immunoinflammatory process of ILD in RA, and these autoantibodies may neutralize and regulate the IL-1alpha activity.
- Subjects :
- Adult
Aged
Anti-Inflammatory Agents therapeutic use
Anti-Inflammatory Agents, Non-Steroidal therapeutic use
Arthritis, Rheumatoid drug therapy
Blood Sedimentation
Carrier Proteins
Case-Control Studies
Cyclic AMP Receptor Protein blood
Female
Humans
L-Lactate Dehydrogenase blood
Lung Diseases, Interstitial blood
Male
Middle Aged
Steroids
Arthritis, Rheumatoid complications
Autoantibodies blood
Interleukin-1 immunology
Lung Diseases, Interstitial etiology
Lung Diseases, Interstitial immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1323-7799
- Volume :
- 5
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Respirology (Carlton, Vic.)
- Publication Type :
- Academic Journal
- Accession number :
- 11192540