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Translational roots for mental retardation?
- Source :
-
Science (New York, N.Y.) [Science] 2000 Oct 27; Vol. 290 (5492), pp. 737. - Publication Year :
- 2000
-
Abstract
- A flurry of findings points to protein translation in the dendrites of neurons as a key feature leading to the changes at synapses that are vital to learning (see main text). And one recent discovery suggests that when this translation goes awry, it can lead to mental retardation.
- Subjects :
- Animals
Fragile X Mental Retardation Protein
Fragile X Syndrome etiology
Fragile X Syndrome genetics
Fragile X Syndrome metabolism
Humans
Intellectual Disability genetics
Intellectual Disability metabolism
Mice
Mutation
Nerve Tissue Proteins metabolism
Dendrites metabolism
Intellectual Disability etiology
Nerve Tissue Proteins genetics
Protein Biosynthesis
RNA-Binding Proteins
Synapses physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0036-8075
- Volume :
- 290
- Issue :
- 5492
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Periodical
- Accession number :
- 11184206
- Full Text :
- https://doi.org/10.1126/science.290.5492.737