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[Experimental bases and primary trials of photochemotherapy of psoriasis by a non-cancerigenic monofunctional furocoumarin, 3-carbethoxypsoralen].
- Source :
-
Comptes rendus des seances de l'Academie des sciences. Serie D, Sciences naturelles [C R Seances Acad Sci D] 1979 Mar 19; Vol. 288 (11), pp. 975-7. - Publication Year :
- 1979
-
Abstract
- The carcinogenic risk of the photochemotherapy (PUVA) with bifunctional furocoumarins such as 8-methoxypsoralen (8-MOP) forming cross-links in cellular DNA has initiated a search for active but less dangerous psoralens. The 3-carbethoxypsoralen (3-CPs), studied in the yeast Saccharomyces cerevisiae, has been very photoactive on DNA forming only monoadditions to DNA. In Mice it was demonstrated that after local or intra-peritoneal administration, 3-CPs is non toxic, non erythematogenic and non carcinogenic in contrast to 8-MOP. A limited study on ten psoriatic patients has shown that after local application 3-CPs exhibits about the same therapeutic activity as 8-MOP.
Details
- Language :
- French
- ISSN :
- 0567-655X
- Volume :
- 288
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Comptes rendus des seances de l'Academie des sciences. Serie D, Sciences naturelles
- Publication Type :
- Academic Journal
- Accession number :
- 111837