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Toluene increases acute thermonociception in mice.
- Source :
-
Behavioural brain research [Behav Brain Res] 2001 May; Vol. 120 (2), pp. 213-20. - Publication Year :
- 2001
-
Abstract
- Toluene is an abused solvent widely used in several commercial products. Recent evidence indicates that this solvent is a non-competitive inhibitor of NMDA receptors. Since NMDA receptors have been implicated in pain, this paper describes studies of the effects of increasing concentrations of inhaled toluene on nociception. Swiss Webster mice were exposed to toluene (500-8000 ppm) in static exposure chambers for 30 min. After completing the exposure period, animals were tested for nociception using the hot plate test. Toluene dose-dependently increased nociception as reflected by shorter latencies for the reflex, paw-lick and escape responses in toluene-treated mice with respect to their controls (animals exposed to air). In order to determine the possible role of opioids in this response, morphine (1-10 mg/kg) was injected before toluene inhalation. Toluene was not able to block morphine-induced antinocieption, however, it produced a shift of the morphine dose-response curve to lower effects, suggesting a physiological antagonism. No potentiation was seen when toluene was administered in combination with naloxone. Present results suggest that toluene increases nociception via neurotransmitter systems others than the glutamatergic.
- Subjects :
- Administration, Inhalation
Analgesics, Opioid pharmacology
Animals
Behavior, Animal drug effects
Dose-Response Relationship, Drug
Hot Temperature
Male
Mice
Morphine pharmacology
Postural Balance drug effects
Reaction Time drug effects
Receptors, N-Methyl-D-Aspartate antagonists & inhibitors
Toluene administration & dosage
Nociceptors drug effects
Pain Measurement drug effects
Toluene pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0166-4328
- Volume :
- 120
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Behavioural brain research
- Publication Type :
- Academic Journal
- Accession number :
- 11182169
- Full Text :
- https://doi.org/10.1016/s0166-4328(00)00375-2