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Mimotopes for tumor-specific T lymphocytes in human cancer determined with combinatorial peptide libraries.
- Source :
-
European journal of immunology [Eur J Immunol] 2001 Jan; Vol. 31 (1), pp. 156-65. - Publication Year :
- 2001
-
Abstract
- Mimotopes of a tumor-associated T cell epitope were determined using randomized and combinatorial peptide libraries and a CD8(+) T cell clone specific for the cutaneous T cell lymphoma cell line MyLa. Antigen recognition by this clone was found to be HLA-B8 restricted. More than 80 % of HLA-matched patients with cutaneous T cell lymphoma had mimotope-specific CD8(+) T cells in their peripheral blood. Mimotope-specific T cells isolated and expanded from a patient lysed MyLa cells in in vitro assays thus demonstrating their cytolytic capacity and tumor specificity. Mimotope vaccination of a patient without detectable mimotope-specific T cells induced frequencies of these cells of up to 1.82 % of the peripheral blood CD8(+) T cells.
Details
- Language :
- English
- ISSN :
- 0014-2980
- Volume :
- 31
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- European journal of immunology
- Publication Type :
- Academic Journal
- Accession number :
- 11169449
- Full Text :
- https://doi.org/10.1002/1521-4141(200101)31:1<156::aid-immu156>3.0.co;2-p