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The expression of the antiproliferative gene ZAC is lost or highly reduced in nonfunctioning pituitary adenomas.
- Source :
-
Cancer research [Cancer Res] 2000 Dec 15; Vol. 60 (24), pp. 6794-9. - Publication Year :
- 2000
-
Abstract
- The ZAC gene encodes a new zinc-finger protein that concomitantly induces apoptosis and cell cycle arrest and localizes to chromosome 6q24-q25, a well-known hot spot related to cancer. ZAC is highly expressed in the anterior pituitary gland, and its ablation by antisense targeting promotes pituitary cell proliferation. Here we investigate ZAC status in pituitary tumors to evaluate its role in pituitary tumorigenesis. Interest ingly, a strong reduction or absence of ZAC mRNA and protein expres sion was detected in nonfunctioning pituitary adenomas, whereas in clin ically active pituitary neoplasias, the decrease in ZAC expression was variable. Loss of expression was not associated with a mutation of the ZAC gene. Our observations suggest that alternative mechanisms of gene inactivation and/or altered regulation of the ZAC gene occur in nonfunctioning pituitary adenomas.
- Subjects :
- Blotting, Western
Cell Division
DNA, Complementary metabolism
ErbB Receptors biosynthesis
Humans
Immunohistochemistry
In Situ Hybridization
Mutation
Oligonucleotides, Antisense metabolism
Pituitary Gland metabolism
RNA, Messenger metabolism
Reverse Transcriptase Polymerase Chain Reaction
Tumor Suppressor Proteins
Zinc Fingers
Adenoma metabolism
Cell Cycle Proteins biosynthesis
Cell Cycle Proteins genetics
Genes, Tumor Suppressor
Pituitary Neoplasms metabolism
Trans-Activators biosynthesis
Trans-Activators genetics
Transcription Factors
Subjects
Details
- Language :
- English
- ISSN :
- 0008-5472
- Volume :
- 60
- Issue :
- 24
- Database :
- MEDLINE
- Journal :
- Cancer research
- Publication Type :
- Academic Journal
- Accession number :
- 11156367