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Loco-regional thrombolysis in the treatment of cerebral venous and sinus thrombosis: report of two cases.
- Source :
-
Acta neurologica Scandinavica [Acta Neurol Scand] 2001 Jan; Vol. 103 (1), pp. 59-63. - Publication Year :
- 2001
-
Abstract
- Although intravenous (i.v.) heparin is widely used as the first line treatment for cerebral venous and sinus thrombosis (CVST), the most appropriate therapy for this disease is still controversial. We report 2 cases of CVST who were successfully treated by means of loco-regional thrombolysis with urokinase. In the first case we chose this treatment instead of i.v. heparin because clinical conditions of the patient appeared critical for life on hospital admission; in the second case loco-regional thrombolysis was performed because a full-dose heparin treatment over 8 days failed to improve the clinical picture of the patient. In the literature, there are no established criteria for the use of loco-regional thrombolysis in CVST. On the basis of our own experience and few previous reports on the matter, we suggest that loco-regional thrombolysis should be considered an appropriate treatment for CVST when patients are at life risk, when an involvement of deep cerebral veins is present or when, after full heparinization, patients are doing poorly clinically.
- Subjects :
- Cerebral Angiography
Drug Therapy, Combination
Female
Heparin administration & dosage
Humans
Infusions, Intravenous
Intracranial Embolism diagnostic imaging
Middle Aged
Sinus Thrombosis, Intracranial diagnostic imaging
Cerebral Veins diagnostic imaging
Intracranial Embolism drug therapy
Sinus Thrombosis, Intracranial drug therapy
Thrombolytic Therapy
Urokinase-Type Plasminogen Activator administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0001-6314
- Volume :
- 103
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Acta neurologica Scandinavica
- Publication Type :
- Academic Journal
- Accession number :
- 11153890
- Full Text :
- https://doi.org/10.1034/j.1600-0404.2001.00058.x