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High mobility group HMGI(Y) protein expression in human colorectal hyperplastic and neoplastic diseases.
- Source :
-
International journal of cancer [Int J Cancer] 2001 Jan 15; Vol. 91 (2), pp. 147-51. - Publication Year :
- 2001
-
Abstract
- HMGI(Y) proteins are overexpressed in experimental and human malignancies, including colon, prostate and thyroid carcinomas. To determine at which step of the carcinogenic process HMGI(Y) induction occurs, we analysed the expression of the HMGI(Y) proteins in hyperplastic, preneoplastic and neoplastic tissues of colorectal origin by immunohistochemistry. All the colorectal carcinomas were HMGI(Y)-positive, whereas no expression was detected in normal colon mucosa tissue. HMGI(Y) expression in adenomas was closely correlated with the degree of cellular atypia. Only 2 of the 18 non-neoplastic polyps tested were HMGI(Y)-positive. These data indicate that HMGI(Y) protein induction is associated with the early stages of neoplastic transformation of colon cells and only rarely with colon cell hyperproliferation.<br /> (Copyright 2001 Wiley-Liss, Inc.)
- Subjects :
- Colon pathology
Colonic Polyps chemistry
Colonic Polyps pathology
Colorectal Neoplasms pathology
HMGA1a Protein
Humans
Hyperplasia
Immunohistochemistry
Adenoma chemistry
Colorectal Neoplasms chemistry
High Mobility Group Proteins analysis
Neoplasm Proteins analysis
Transcription Factors analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0020-7136
- Volume :
- 91
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 11146437
- Full Text :
- https://doi.org/10.1002/1097-0215(200002)9999:9999<::aid-ijc1033>3.3.co;2-m