Back to Search
Start Over
Lymphocyte populations in Parkinson's disease and in rat models of parkinsonism.
- Source :
-
Journal of neuroimmunology [J Neuroimmunol] 2001 Feb 01; Vol. 113 (1), pp. 146-52. - Publication Year :
- 2001
-
Abstract
- To assess the involvement of the immune system in Parkinson's disease we studied the phenotype of circulating lymphocytes in 30 untreated and 34 treated patients. We found a numeric decrease in helper T cells (higher in CD4(+)CD45RA(+) than in CD4(+)CD29(+)) and B cells, and a rise in activated, CD4(+)CD25(+) lymphocytes that was correlated with lymphocyte depletion. All these alterations were independent of levodopa treatment. In addition, we performed striatal dopamine depletion in rats with either MPP(+) or 6-OHDA, showing that MPP(+) but not 6-OHDA can increase CD4(+)CD25(+) lymphocytes. Thus, mechanisms other than dopamine deficit may explain the immune activation in Parkinson's disease.
- Subjects :
- Aged
Animals
CD4-Positive T-Lymphocytes chemistry
CD4-Positive T-Lymphocytes cytology
Disease Models, Animal
Humans
Leukocyte Common Antigens analysis
Leukocyte Common Antigens immunology
Lymphocyte Activation immunology
Male
Middle Aged
Oxidopamine
Rats
Rats, Sprague-Dawley
Receptors, Interleukin-2 blood
Receptors, Interleukin-2 immunology
Solubility
Sympatholytics
CD4-Positive T-Lymphocytes immunology
MPTP Poisoning immunology
Parkinson Disease immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0165-5728
- Volume :
- 113
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 11137586
- Full Text :
- https://doi.org/10.1016/s0165-5728(00)00422-7