Back to Search
Start Over
Calpain-dependent proteolysis of NF2 protein: involvement in schwannomas and meningiomas.
- Source :
-
Neuropathology : official journal of the Japanese Society of Neuropathology [Neuropathology] 2000 Sep; Vol. 20 (3), pp. 153-60. - Publication Year :
- 2000
-
Abstract
- The neurofibromatosis type 2 (NF2) protein, known as merlin or schwannomin, is a tumor suppressor, and the NF2 gene has been found to be mutated in the majority of schwannomas and meningiomas, including both sporadically occurring and familial NF2 cases. Although the development of these tumors depends on the loss of merlin, the presence of tumors lacking detectable NF2 mutations suggests different mechanisms for inactivating merlin. Recent studies have demonstrated cleavage of merlin by calpain, a calcium-dependent neutral cysteine protease, and marked activation of the calpain system resulting in the degradation of merlin in these tumors. Increased turnover of merlin by calpain in some schwannomas and meningiomas exemplifies tumorigenesis linked to the calpain-mediated proteolytic pathway.
- Subjects :
- Calpain genetics
Humans
Membrane Proteins genetics
Meningioma genetics
Mutation physiology
Neurilemmoma genetics
Neurofibromatosis 2 genetics
Neurofibromatosis 2 physiopathology
Neurofibromin 2
Peptide Hydrolases genetics
Calpain metabolism
Genes, Neurofibromatosis 2 physiology
Membrane Proteins metabolism
Meningioma metabolism
Neurilemmoma metabolism
Neurofibromatosis 2 metabolism
Peptide Hydrolases metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0919-6544
- Volume :
- 20
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Neuropathology : official journal of the Japanese Society of Neuropathology
- Publication Type :
- Academic Journal
- Accession number :
- 11132929
- Full Text :
- https://doi.org/10.1046/j.1440-1789.2000.00326.x