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Treating ambulatory ischemia in coronary disease by manipulating the cell biology of atherosclerosis.
- Source :
-
Current atherosclerosis reports [Curr Atheroscler Rep] 2000 Jul; Vol. 2 (4), pp. 321-6. - Publication Year :
- 2000
-
Abstract
- Obstructive coronary artery disease is the most common cause of morbidity and mortality in the developed world. Our understanding of the pathobiology of coronary atherosclerosis provides us with new opportunities to reduce myocardial ischemia by interventions that address these mechanisms directly. These interventions include lipid-lowering therapies that improve local coronary vasomotion, inflammation, and the procoagulant state. These interventions have also been shown to result in important reductions in clinical events, including angina pectoris, myocardial ischemia and infarction, and death. Ambulatory electrocardiography provides a versatile and quantifiable measure of regional myocardial ischemia. Reductions in ischemia, as quantified by this diagnostic modality, are associated with improved clinical outcomes that may reflect improvements in the cellular pathophysiology of coronary atherosclerosis. This review discusses new information regarding the interactions between low-density lipoprotein cholesterol, the cell biology of atherosclerosis, and the activity of ischemia in patients with coronary artery disease.
- Subjects :
- Cholesterol, LDL blood
Coronary Artery Disease complications
Electrocardiography, Ambulatory
Endothelium, Vascular physiopathology
Humans
Lovastatin therapeutic use
Male
Myocardial Ischemia diagnosis
Myocardial Ischemia etiology
Risk Factors
Anticholesteremic Agents therapeutic use
Coronary Artery Disease physiopathology
Myocardial Ischemia therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1523-3804
- Volume :
- 2
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Current atherosclerosis reports
- Publication Type :
- Academic Journal
- Accession number :
- 11122761
- Full Text :
- https://doi.org/10.1007/s11883-000-0066-4