The 8p12 myeloproliferative disorder. t(8;19)(p12;q13.3): a novel translocation involving the FGFR1 gene.

Authors :: Mugneret F
Chaffanet M
Maynadié M
Guasch G
Favre B
Casasnovas O
Birnbaum D
Pébusque MJ
Source :: British journal of haematology [Br J Haematol] 2000 Nov; Vol. 111 (2), pp. 647-9.
Publication Year :: 2000
Abstract: Translocations affecting the chromosomal locus 8p12 are hallmarks of an atypical stem cell myeloproliferative disorder. These events disrupt the fibroblast growth factor receptor 1 (FGFR1) gene and fuse the FGFR1 C-terminus catalytic domain with unrelated proteins. Here, we report on the characterization of the 19q13.3 locus as the fifth FGFR1 chromosomal partner.

Subjects :: Aged
Humans
In Situ Hybridization, Fluorescence
Male
Receptor, Fibroblast Growth Factor, Type 1
Chromosomes, Human, Pair 19
Chromosomes, Human, Pair 8
Myeloproliferative Disorders genetics
Receptor Protein-Tyrosine Kinases genetics
Receptors, Fibroblast Growth Factor genetics
Translocation, Genetic

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