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The parathyroid hormones: bone-forming agents for treatment of osteoporosis.
- Source :
-
Medscape women's health [Medscape Womens Health] 2000 Sep-Oct; Vol. 5 (5), pp. E5. - Publication Year :
- 2000
-
Abstract
- This is a 3-part article. Part 1 is an overview of bone formation and resorption and the consequences of estrogen loss on bone. Part 2 comprehensively reviews the most current data on the ability of a family of potent osteoblast-stimulating bone-builders, the native 84-amino-acid parathyroid hormone (PTH), and certain of its 31- to 38- amino-acid fragments to stimulate the growth of animal and human bones. These PTHs are currently in, or about to enter, clinical trial as treatment for postmenopausal osteoporosis. Part 3 provides a detailed consideration of how these PTHs might stimulate bone growth via PTH receptor signaling.
- Subjects :
- Animals
Bone Density drug effects
Bone Regeneration physiology
Bone Remodeling drug effects
Bone Remodeling physiology
Fractures, Bone drug therapy
Humans
Bone Development physiology
Bone Regeneration drug effects
Osteoporosis drug therapy
Parathyroid Hormone physiology
Parathyroid Hormone therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1521-2076
- Volume :
- 5
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Medscape women's health
- Publication Type :
- Academic Journal
- Accession number :
- 11113778