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[Experimental study of hemostimulating properties of the tablet form of recombinant human erythropoetin].
- Source :
-
Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2000 Sep-Oct; Vol. 63 (5), pp. 37-40. - Publication Year :
- 2000
-
Abstract
- Specific biological activity of the domestic preparation of recombinant human erythropoietin (RHEPO) in an original pill form was experimentally studied in vitro and in vivo. Administration of the RHEPO parent substance at a concentration of 0.5 10 U/ml significantly accelerated the growth of erythroid colony-forming cells (CFU-E) in the culture of intact nonadherent myelokaryocytes. The erythropoiesis-stimulating properties of the new RHEPO preparation are comparable with those of the well-known injection preparations. The drug action is related to increasing the erythroid cell content in the bone marrow and the reticulocyte and erythrocyte counts in the peripheral blood.
- Subjects :
- Administration, Oral
Animals
Blood Cell Count
Cell Line
Colony-Forming Units Assay
Epoetin Alfa
Erythropoiesis drug effects
Erythropoietin administration & dosage
Humans
Male
Mice
Mice, Inbred CBA
Recombinant Proteins administration & dosage
Recombinant Proteins pharmacology
Reticulocytes drug effects
Tablets
Erythropoietin pharmacology
Hematopoiesis drug effects
Subjects
Details
- Language :
- Russian
- ISSN :
- 0869-2092
- Volume :
- 63
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Eksperimental'naia i klinicheskaia farmakologiia
- Publication Type :
- Academic Journal
- Accession number :
- 11109524