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Oncocytic mucoepidermoid carcinoma of the parotid gland: report of a case with DNA ploidy analysis and review of the literature.
- Source :
-
Pathology international [Pathol Int] 2000 Nov; Vol. 50 (11), pp. 905-9. - Publication Year :
- 2000
-
Abstract
- A 44-year-old female presented with a painful mass in the left parotid gland. Histologic examination revealed the characteristic picture of oncocytic mucoepidermoid carcinoma (OMEC) composed mainly of sheets of oncocytic cells with uniform nuclei and eosinophilic cytoplasm, focally smaller epidermoid cells surrounding poorly formed glandular spaces, and a few cystic structures lined by well-differentiated mucous cells with intracytoplasmic mucin. Immunohistochemical staining with antimitochondrial antibody showed granular cytoplasmic positivity in oncocytic cells. The resulting histogram for DNA ploidy analysis was of diploid type. OMEC of the parotid gland is a recently described rare neoplasm. Only six cases have been previously reported in the literature. For an accurate approach in the management of patients, OMEC should be considered in the differential diagnosis of oncocytic lesions of the parotid gland, most of which are benign.
- Subjects :
- Adult
Antigens, Neoplasm analysis
Biomarkers, Tumor analysis
Carcinoma, Mucoepidermoid chemistry
Carcinoma, Mucoepidermoid genetics
Carcinoma, Mucoepidermoid surgery
DNA, Neoplasm analysis
Disease-Free Survival
Female
Humans
Parotid Neoplasms chemistry
Parotid Neoplasms genetics
Parotid Neoplasms surgery
Treatment Outcome
Carcinoma, Mucoepidermoid pathology
Parotid Neoplasms pathology
Ploidies
Subjects
Details
- Language :
- English
- ISSN :
- 1320-5463
- Volume :
- 50
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Pathology international
- Publication Type :
- Academic Journal
- Accession number :
- 11107068
- Full Text :
- https://doi.org/10.1046/j.1440-1827.2000.01129.x