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Inhalation exposure to white spirit causes region-dependent alterations in the levels of glial fibrillary acidic protein.
- Source :
-
Neurotoxicology and teratology [Neurotoxicol Teratol] 2000 Sep-Oct; Vol. 22 (5), pp. 725-31. - Publication Year :
- 2000
-
Abstract
- Enhanced expression of glial fibrillary acidic protein (GFAP) is known to be associated with toxicant-induced gliosis, a homotypic response of the central nervous system to neural injury. A variety of neurochemical and neurophysiological effects have been observed in experimental animals exposed to white spirit, but a linkage of such effects to neural damage has not been established. Here we evaluated the regional levels of GFAP to assess potential sites of CNS damage in the rat, following exposure to dearomatized and aromatic white spirit. Samples from rats exposed to dearomatized white spirit were assayed for GFAP levels in the United States and Denmark. The results were remarkably similar between countries. Small region-dependent increases and decreases in GFAP were observed with the cerebellum showing the most consistent effects (increases). In contrast, samples from rats exposed to aromatic white spirit showed large (as much as 150% of control) increases in regional levels of GFAP; again, the cerebellum showed the most consistent effects. The data are indicative of an aromatic white-spirit-induced astrogliosis in several regions of the rat CNS and suggest that chronic exposure to this solvent may be associated with underlying neural damage.
- Subjects :
- Administration, Inhalation
Animals
Behavior, Animal drug effects
Body Weight drug effects
Central Nervous System metabolism
Central Nervous System pathology
Central Nervous System Diseases chemically induced
Central Nervous System Diseases mortality
Cerebellum drug effects
Cerebellum metabolism
Cerebral Cortex drug effects
Cerebral Cortex metabolism
Dose-Response Relationship, Drug
Glial Fibrillary Acidic Protein drug effects
Glial Fibrillary Acidic Protein metabolism
Hippocampus drug effects
Hippocampus metabolism
Hypothalamus drug effects
Hypothalamus metabolism
Immunoassay
Male
Medulla Oblongata drug effects
Medulla Oblongata metabolism
Morbidity
Organ Size drug effects
Pons drug effects
Pons metabolism
Rats
Thalamus drug effects
Thalamus metabolism
Central Nervous System drug effects
Hydrocarbons toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 0892-0362
- Volume :
- 22
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Neurotoxicology and teratology
- Publication Type :
- Academic Journal
- Accession number :
- 11106865
- Full Text :
- https://doi.org/10.1016/s0892-0362(00)00098-2