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Neuroprotective effects of Ginkgo biloba extract in brain ischemia are mediated by inhibition of nitric oxide synthesis.
- Source :
-
Life sciences [Life Sci] 2000 Oct 20; Vol. 67 (22), pp. 2673-83. - Publication Year :
- 2000
-
Abstract
- We studied the effects of pre-treatment (15 days) with oral administration of Ginkgo biloba extract (Ph-Gb 37.5-150 mg/kg) on brain malonildialdehyde (MDA), brain edema, brain nitrite and nitrate and delayed neuronal death following transient cerebral ischemia in the Mongolian gerbil. Survival was not modified, however, pre-treatment with Ginkgo biloba significantly and in a dose-dependent way reduced post-ischemic brain MDA levels and post-ischemic brain edema. Delayed neuronal death in the CA1 of the hippocampus was attenuated by the highest dose of the extract. Increase of nitrite and nitrate was observed after cerebral ischemia in the hippocampus and it was dose-dependently reduced in animals pretreated with Ph-Gb, thus suggesting that neuroprotective effects of Ginkgo biloba may be due to an inhibitory action on nitric oxide formation.
- Subjects :
- Administration, Oral
Animals
Brain drug effects
Brain metabolism
Cell Death drug effects
Dose-Response Relationship, Drug
Gerbillinae
Ischemic Attack, Transient drug therapy
Ischemic Attack, Transient pathology
Male
Malondialdehyde metabolism
Neurons drug effects
Neurons pathology
Neurons physiology
Nitrates metabolism
Nitrites metabolism
Reperfusion Injury
Tissue Extracts administration & dosage
Brain physiopathology
Brain Edema prevention & control
Ginkgo biloba
Ischemic Attack, Transient physiopathology
Neuroprotective Agents
Plants, Medicinal
Tissue Extracts pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0024-3205
- Volume :
- 67
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- Life sciences
- Publication Type :
- Academic Journal
- Accession number :
- 11105983
- Full Text :
- https://doi.org/10.1016/s0024-3205(00)00858-4