Back to Search
Start Over
Abnormalities of motor cortical excitability are not correlated with clinical features in atypical parkinsonism.
- Source :
-
Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2000 Nov; Vol. 15 (6), pp. 1210-4. - Publication Year :
- 2000
-
Abstract
- Objective: To evaluate the specificity of motor cortical excitability changes in parkinsonian syndromes and their relevance to the pathophysiology of cardinal parkinsonian features.<br />Methods: Paired transcranial magnetic stimulation (TMS) was used to assess cortico-cortical inhibition (CCI) and facilitation (CCF) in the opponens pollicis muscle of patients with atypical, non-L-dopa- (LD) responsive parkinsonism.<br />Results: Compared with age-matched normal control subjects, CCI (interstimulus interval [ISI], 3 ms) was significantly reduced in 10 patients with predominantly parkinsonian multiple system atrophy (MSA-P) and in seven with vascular parkinsonism (VP), but not in four with predominantly cerebellar MSA. No significant change of CCF (ISI, 12 ms) was observed. No correlation was found between the amount of CCI and clinical status as evaluated with the Unified Parkinson's Disease Rating Scale (UPDRS). In 10 patients (5 MSA-P, 5 VP), CCI was significantly increased by LD acute administration without concurrent clinical changes.<br />Conclusions: Abnormalities of CCI are not peculiar to idiopathic Parkinson's disease and seem unlikely to underlie any specific parkinsonian feature, but rather possibly reflect a nonspecific imbalance of inhibitory and facilitatory motor cortical circuits.
- Subjects :
- Adult
Aged
Antiparkinson Agents administration & dosage
Basal Ganglia Cerebrovascular Disease physiopathology
Case-Control Studies
Electromyography
Female
Humans
Levodopa administration & dosage
Magnetoencephalography
Male
Middle Aged
Multiple System Atrophy physiopathology
Parkinsonian Disorders etiology
Statistics, Nonparametric
Basal Ganglia Cerebrovascular Disease complications
Evoked Potentials, Motor drug effects
Magnetics
Motor Cortex physiopathology
Multiple System Atrophy complications
Parkinsonian Disorders physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0885-3185
- Volume :
- 15
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Movement disorders : official journal of the Movement Disorder Society
- Publication Type :
- Academic Journal
- Accession number :
- 11104207
- Full Text :
- https://doi.org/10.1002/1531-8257(200011)15:6<1210::aid-mds1022>3.0.co;2-r