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The development and expression of locomotor sensitization to nicotine in the presence of ibogaine.
- Source :
-
Behavioural pharmacology [Behav Pharmacol] 2000 Aug; Vol. 11 (5), pp. 431-6. - Publication Year :
- 2000
-
Abstract
- Ibogaine is a naturally occurring psychoactive alkaloid with claimed efficacy in the treatment of certain drug addictions, including nicotine. It has been reported to be a non-competitive blocker of nicotinic receptors, with a potent inhibitory action on nicotinic acetylcholine receptor-mediated catecholamine release. We have investigated the effect of different doses of ibogaine on the development and expression of sensitization to the locomotor stimulant effect of nicotine in rats, a facilitatory process in which a history of exposure to nicotine results in enhanced locomotor activity when the same dose of nicotine is administered repeatedly. The effects were determined of co-administering ibogaine (0.0, 5.0 or 10 mg/kg i.p.) with nicotine (0.0 or 0.4 mg/kg s.c.) daily for 21 days. Dose-response curves for nicotine (0.04-0.8 mg/kg s.c.) were then determined in groups of 10 rats. There was clear sensitization of the locomotor activity produced by nicotine in photocell activity cages but co-administration of ibogaine with nicotine had no effect on the degree of sensitization. Ibogaine (5-20 mg/kg) itself did not influence locomotor activity and was also without effect on the expression of the sensitized response to 0.4 mg/kg of nicotine (n = 10). Thus, there was no evidence that ibogaine may retard or suppress sensitization to nicotine.
- Subjects :
- Animals
Dose-Response Relationship, Drug
Excitatory Amino Acid Antagonists administration & dosage
Ganglionic Stimulants administration & dosage
Ibogaine administration & dosage
Male
Nicotine administration & dosage
Rats
Substance-Related Disorders physiopathology
Excitatory Amino Acid Antagonists pharmacology
Ganglionic Stimulants pharmacology
Ibogaine pharmacology
Locomotion drug effects
Nicotine pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0955-8810
- Volume :
- 11
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Behavioural pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 11103895
- Full Text :
- https://doi.org/10.1097/00008877-200008000-00009