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Electrophysiological, neuropsychological and clinical findings in multiple sclerosis patients receiving interferon beta-1b: a 1-year follow-up.
- Source :
-
European neurology [Eur Neurol] 2000; Vol. 44 (4), pp. 205-9. - Publication Year :
- 2000
-
Abstract
- We assessed serial event-related potentials (ERPs) as well as neuropsychological and clinical test findings in a group of multiple sclerosis (MS) patients (n = 14) treated with interferon beta-1b (INF-beta-1b) compared to normal controls (n = 14). All investigations were done within 1 week before INF-beta-1b therapy was started and 12 months later. An auditory oddball paradigm was employed. No significant differences in the N100, P200, N200 or P300 latencies between patients and control group were found, but 3 out of 14 MS patients developed abnormal P300 latencies (more than 2 standard errors from the mean) after 1 year of INF-beta-1b therapy. This was not reflected by the respective neurological impairment as assessed by the Expanded Disability Status Scale score. ERPs might be a useful tool in clinical studies in order to evaluate drug effects on cognition, but for a final statement, the analysis of ERPs in a larger group of patients is required.<br /> (Copyright 2000 S. Karger AG, Basel)
- Subjects :
- Adult
Cognition Disorders drug therapy
Disability Evaluation
Disease Progression
Event-Related Potentials, P300 drug effects
Event-Related Potentials, P300 physiology
Female
Follow-Up Studies
Humans
Interferon beta-1a
Interferon beta-1b
Male
Middle Aged
Multiple Sclerosis physiopathology
Neuropsychological Tests statistics & numerical data
Psychomotor Performance drug effects
Psychomotor Performance physiology
Reaction Time drug effects
Reaction Time physiology
Treatment Outcome
Adjuvants, Immunologic administration & dosage
Cognition Disorders diagnosis
Cognition Disorders etiology
Interferon-beta administration & dosage
Multiple Sclerosis complications
Multiple Sclerosis drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0014-3022
- Volume :
- 44
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- European neurology
- Publication Type :
- Academic Journal
- Accession number :
- 11096218
- Full Text :
- https://doi.org/10.1159/000008237