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Functional adrenocorticotropic hormone receptor in cultured human vascular endothelial cells : possible role in control of blood pressure.
- Source :
-
Hypertension (Dallas, Tex. : 1979) [Hypertension] 2000 Nov; Vol. 36 (5), pp. 862-5. - Publication Year :
- 2000
-
Abstract
- Hypertension is a prominent feature of patients with Cushing's disease and ectopic adrenocorticotropic hormone (ACTH) syndrome, who have elevated ACTH levels. Chronic administration of ACTH (1-24) also raises blood pressure in humans. This effect has been postulated to be due to ACTH-induced increases in cortisol secretion in the adrenal gland. It is well known that cortisol increases vascular tone by potentiating the vasoconstrictor action of a number of pressor hormones. In the present study, we show direct evidence that human aortic endothelial cells possess the ACTH receptor. 11beta-Dehydrogenation, converting cortisol to its inactive metabolite, cortisone, mediated by vascular 11beta-hydroxysteroid dehydrogenase type 2 is essential for the control of vascular tone, and the reduced activity may be relevant to the pathogenesis of hypertension. We found that ACTH (1-24) dose-dependently decreased the gene expression and enzyme activity of 11beta-hydroxysteroid dehydrogenase type 2 in these cells, and the decrease was partially abolished by a selective ACTH receptor antagonist. This may indicate that ACTH potentiates the action of cortisol through its direct effect on the vasculature. Therefore, the present study provides important information for understanding the mechanism of ACTH-induced hypertension.
- Subjects :
- 11-beta-Hydroxysteroid Dehydrogenases
Aorta cytology
Aorta drug effects
Aorta physiology
Blood Pressure drug effects
Cells, Cultured
Corticosterone pharmacology
Cosyntropin pharmacology
Endothelium, Vascular cytology
Endothelium, Vascular drug effects
Gene Expression drug effects
Humans
Hydroxysteroid Dehydrogenases pharmacology
Hypertension chemically induced
Hypertension physiopathology
Receptors, Corticotropin drug effects
Receptors, Corticotropin genetics
Reverse Transcriptase Polymerase Chain Reaction
Blood Pressure physiology
Endothelium, Vascular physiology
Receptors, Corticotropin physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4563
- Volume :
- 36
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Hypertension (Dallas, Tex. : 1979)
- Publication Type :
- Academic Journal
- Accession number :
- 11082157
- Full Text :
- https://doi.org/10.1161/01.hyp.36.5.862