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Pharmacokinetics and urinary excretion of sulphadimidine in buffalo calves.
- Source :
-
Journal of veterinary medicine. A, Physiology, pathology, clinical medicine [J Vet Med A Physiol Pathol Clin Med] 2000 Oct; Vol. 47 (8), pp. 501-5. - Publication Year :
- 2000
-
Abstract
- Pharmacokinetics and urinary excretion of sulphadimidine (SDI) were determined in buffalo calves following single oral administration (150 mg/kg). The plasma levels of free sulphadimidine were above minimum effective therapeutic concentration (> 40 micrograms/ml) between 4 and 12 h and the N4-acetylated form of the drug was in the range of 7.2-19.3%. Kinetic evaluation of plasma levels was performed using a two-compartment open model. The absorption and elimination half-lives of SDI were 3.01 and 11.94 h, respectively. Based on this study, an optimal dosage regimen of sulphadimidine in buffalo calves would be 100 mg/kg, followed by 50 mg/kg at 12 h intervals. Sulphadimidine was mainly excreted in the urine as free amine. The percentage of N4-acetyl sulphadimidine in urine was comparatively higher than in plasma.
- Subjects :
- Animals
Anti-Infective Agents administration & dosage
Anti-Infective Agents blood
Anti-Infective Agents urine
Area Under Curve
Half-Life
Male
Sulfamethazine administration & dosage
Sulfamethazine blood
Sulfamethazine urine
Anti-Infective Agents pharmacokinetics
Buffaloes physiology
Sulfamethazine pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 0931-184X
- Volume :
- 47
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of veterinary medicine. A, Physiology, pathology, clinical medicine
- Publication Type :
- Academic Journal
- Accession number :
- 11075542
- Full Text :
- https://doi.org/10.1046/j.1439-0442.2000.00311.x