Back to Search
Start Over
Overview of evolving strategies incorporating prostate-specific membrane antigen as target for therapy.
- Source :
-
Molecular urology [Mol Urol] 2000 Fall; Vol. 4 (3), pp. 217-22;discussion 223. - Publication Year :
- 2000
-
Abstract
- Prostate-specific membrane antigen (PSMA) is a potential target in prostate cancer patients because it is very highly expressed and because it has been reported to be upregulated by androgen deprivation. This overview addresses the expression of the PSMA gene in terms of the promoter and enhancer and how that may play a role in gene therapy. We also review PSMA as a target for antibodies for imaging and treatment and the development of a novel hybrid T-cell receptor that combines the specificity of anti-PSMA antibodies with that of T-cell receptor activation when introduced into primary lymphocytes by retroviral-mediated gene transfer. We also discuss our recent findings on the expression of a PSMA-like gene and how that understanding allows specific targeting of PSMA.
- Subjects :
- Animals
Antibodies, Neoplasm immunology
Antigens, Neoplasm genetics
Antigens, Neoplasm immunology
Antigens, Surface genetics
Antigens, Surface immunology
Antigens, Surface metabolism
Antineoplastic Agents pharmacology
Antineoplastic Agents therapeutic use
Breast Neoplasms genetics
Breast Neoplasms metabolism
Carboxypeptidases genetics
Carboxypeptidases immunology
Enhancer Elements, Genetic
Enzyme Inhibitors pharmacology
Female
Genetic Therapy
Glutamate Carboxypeptidase II
Humans
Male
Prodrugs metabolism
Promoter Regions, Genetic
Prostatic Neoplasms blood supply
Prostatic Neoplasms genetics
Receptors, Antigen, T-Cell immunology
Tumor Cells, Cultured
Antigens, Neoplasm metabolism
Carboxypeptidases metabolism
Prostatic Neoplasms enzymology
Prostatic Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1091-5362
- Volume :
- 4
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Molecular urology
- Publication Type :
- Academic Journal
- Accession number :
- 11062377