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Relationships between cerebrovascular events, APOE polymorphism and Alzheimer's disease in a community sample.
- Source :
-
Neuroepidemiology [Neuroepidemiology] 2000 Nov-Dec; Vol. 19 (6), pp. 320-6. - Publication Year :
- 2000
-
Abstract
- To investigate whether the APOE*4 allele modified the relationship between cerebrovascular events and Alzheimer's disease (AD), we collected evidence of previous stroke or transient ischemic attack (TIA) and determined APOE genotype among 102 subjects with AD and 375 nondemented subjects in a community-based study of dementia. Subjects with a history of stroke or TIA were twice as likely to have AD as subjects without such a history. However, APOE*4 carriers with a history of stroke/TIA were 5 times more likely than APOE*4 carriers without such a history to have AD (odds ratio = 5.3, 95% confidence interval = 1.4-20.9). History of stroke/TIA had little effect on the likelihood of having AD in subjects without an APOE*4 allele.<br /> (Copyright 2000 S. Karger AG, Basel)
- Subjects :
- Aged
Case-Control Studies
Catchment Area, Health
Cerebrovascular Disorders epidemiology
Cerebrovascular Disorders genetics
Cognition Disorders diagnosis
Cognition Disorders epidemiology
Cognition Disorders etiology
Community Mental Health Services
Female
Genotype
Humans
Male
Neuropsychological Tests
Pennsylvania epidemiology
Polymerase Chain Reaction
Prospective Studies
Surveys and Questionnaires
Alzheimer Disease complications
Alzheimer Disease epidemiology
Alzheimer Disease genetics
Apolipoproteins E genetics
Cerebrovascular Disorders complications
Polymorphism, Genetic genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0251-5350
- Volume :
- 19
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Neuroepidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 11060506
- Full Text :
- https://doi.org/10.1159/000026271