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Familial papillary thyroid carcinoma: genetics, criteria for diagnosis, clinical features, and surgical treatment.
- Source :
-
World journal of surgery [World J Surg] 2000 Nov; Vol. 24 (11), pp. 1409-17. - Publication Year :
- 2000
-
Abstract
- Hereditable predisposition to papillary thyroid carcinoma (PTC) and multinodular goiter (MNG) without evidence of an association with other malignancies as a distinct entity was recognized only recently. A meta-review of the literature on familial PTC (FPTC) was undertaken, and characteristics of families with frequent occurrence of PTC or MNG (or both) were summarized. A database on thyroid cancer patients maintained in our institution was searched for potential FPTC families. Clinical examinations were performed in 6 of 12 Hannover kindreds identified, and blood samples of all family members were collected for genetic analyses. Clinical presentations and histopathologic features of the FPTC cases were compiled. Based on the FPTC meta-review and own experience, predictive criteria to identify families at risk were developed: Exclusion criteria were previous radiation exposure and coincidence with neoplasia syndromes. Primary criteria for susceptibility to FPTC are (1) PTC in two or more first-degree relatives and (2) MNG in at least three first- or second-degree relatives of a PTC patient. Secondary criteria are diagnosis in a patient younger than 33 years, multifocal or bilateral PTC, organ-exceeding tumor growth (T4), metastasis (N1, M1), and familial accumulation of adolescent-onset thyroid disease. A hereditary predisposition to PTC is considered if both primary criteria or one primary criterion plus three secondary criteria are present. Family history-taking is recommended for all PTC patients to identify FPTC kindreds at risk. Blood relatives of FPTC index patients who harbor MNG should undergo thorough and regular clinical screening. Suspicious lesions should prompt early surgical intervention.
- Subjects :
- Adolescent
Adult
Aged
Carcinoma, Papillary diagnosis
Female
Humans
Male
Middle Aged
Pedigree
Prognosis
Risk Assessment
Thyroid Neoplasms diagnosis
Thyroid Neoplasms physiopathology
Treatment Outcome
Carcinoma, Papillary genetics
Carcinoma, Papillary surgery
Genetic Predisposition to Disease
Thyroid Neoplasms genetics
Thyroid Neoplasms surgery
Thyroidectomy methods
Subjects
Details
- Language :
- English
- ISSN :
- 0364-2313
- Volume :
- 24
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- World journal of surgery
- Publication Type :
- Academic Journal
- Accession number :
- 11038215
- Full Text :
- https://doi.org/10.1007/s002680010233