[Loss of heterozygosity in the 9p21 region as an inactivation mechanism of the p16 suppressor gene].

Authors :: Maestro de las Casas ML
Sanz-Casla MT
del Barco V
Moreno J
Zanna I
Redondo E
Fernández C
Izquierdo L
Resel Estévez L
Source :: Archivos espanoles de urologia [Arch Esp Urol] 2000 Sep; Vol. 53 (7), pp. 603-9.
Publication Year :: 2000
Abstract: Objective: To determine the loss of heterozygosity (LOH) on 9p21 (locus D9S1747) in patients with renal carcinoma by analysis of microsatellite polymorphisms.<br />Methods: 40 patients with sporadic renal cancer were studied. LOH on 9p21 was performed by analysis of microsatellite polymorphisms.<br />Results: 23.7% showed LOH on 9p21. No correlation was found between this genetic alteration and tumor features.<br />Conclusions: LOH on 9p21 was found in 23.7% of the patients in this series. LOH was found in 26.9% of renal cell carcinomas, 25% of papillary carcinomas and 25% of Bellini duct carcinomas. LOH was not found in the other histological types.

Subjects :: Adult
Aged
Aged, 80 and over
Female
Humans
Male
Microsatellite Repeats
Middle Aged
Polymorphism, Genetic
Carcinoma, Papillary genetics
Carcinoma, Renal Cell genetics
Chromosomes, Human, Pair 9 genetics
Genes, p16 genetics
Kidney Neoplasms genetics
Loss of Heterozygosity

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